Applications

Active natural molecules (secondary metabolites)

The traditional method of obtaining secondary metabolites, such as stilbenes and alkaloids, involves extracting them directly from plants grown in their natural habitats or greenhouses. However, this process is influenced by various factors that can affect the yield. Samabriva’s technology provides several advantages over traditional methods. Our technology enables the production of secondary plant metabolites with greater efficiency, consistency, and purity while reducing the environmental impact.

An environmentally friendly, economical, sustainable, simple, local, and secure process that can be carried out independently.

Current system

1. Grown in open fields in competition with food crops
2. Large footprint
3. Geopolitical risks
4. Seasonality
5. Long production cycle
6. Climate change risk
7. High carbon footprint (from farming and transport) and associated cost
8. Low molecule content per kilogram of plant

Samabriva’s process

1. Contained and controlled production
2. Compact footprint
3. Control of the supply chain
4. Year-round continuous production
5. No climate risk for greater batch-to-batch consistency
6. Low carbon footprint (no light, heat or transport)
7. Higher yield of desired molecule per kilogram of plant material
8. Cost-effective purification

Examples of high value plant-based molecules:

A wide range of molecules could potentially be produced using hairy roots:

Recombinant proteins

Our hairy root system offers a cost-effective (lower CAPEX and COGS) solution for producing recombinant proteins with several advantages over traditional cell line cultures. The process combines the benefits of higher eukaryotic cells, including efficient protein folding, competitive stability, and reproducibility. This innovative process is similar to traditional cell line cultures, enabling us to seamlessly apply regulatory guidelines for the manufacturing of culture cell lines. These guidelines include confinement measures, the use of Master and Working “Root” Banks, and in-process controls to ensure the quality and safety of the final product.