Active natural molecules (secondary metabolites)

Secondary metabolites (such as stilbenes and alkaloids) are traditionally extracted from plants grown in fields or greenhouses. Factors like environmental variability can adversely affect yields.

Samabriva’s technology enables the production of secondary plant metabolites with greater efficiency, consistency, and purity while reducing the environmental impact.

Our bioproduction system is a more sustainable, cost-effective way to make biomolecules all year round, in any location without complex supply chains.

Current system

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Samabriva’s process

Examples of high value plant-based molecules:

A wide range of molecules could potentially be produced using hairy roots:

Recombinant proteins

Our hairy root system offers a lower CAPEX and COGS solution for producing recombinant proteins. The process delivers superior protein production with all the benefits of eukaryotic cell culture: precise folding, enhanced stability and consistent results.

The process is similar to traditional cell line cultures as it allows us to seamlessly apply regulatory guidelines such as confinement measures, the use of Master and Working “Root” Banks, and in-process controls to ensure the quality and safety of the final product.

Robust and highly flexible platform easily transferable anywhere in the world.

KEY BENEFITS

1

Low CAPEX and COGS

Cost reduced by 50-70% compared with CHO

2

Stable production process

Over 97% liter retention with <3% growth rate variation after 70+ sub-cultures

3

Straightforward technology

Plug-and-play process that’s easily transferable worldwide

4

Scalable

Horizontal and vertical scale-up in line with GMP requirements

5

Highly productive

1,5g/L for recombinant proteins

6

Animal component free

Proteins produced from an edible plant with no risk of animal virus contamination

7

Simplified purification (DSP)

Secretion of protein product into the media

8

Positive feedback

From the French regulatory agency (ANSM)

Examples of recombinant proteins: